Arja Pasternack Selected Research

Activins (Activin)

1/2021	A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.
1/2021	The Activin/Follistatin Axis Is Severely Deregulated in COVID-19 and Independently Associated With In-Hospital Mortality.
1/2021	Muscle follistatin gene delivery increases muscle protein synthesis independent of periodical physical inactivity and fasting.
7/2020	Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention.
4/2020	Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development.
1/2019	Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.
1/2017	Activin inhibition limits early innate immune response in rat kidney allografts-a pilot study.
1/2017	Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy.
12/2016	Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.
3/2015	Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.

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Arja Pasternack Research Topics

Disease

4	COVID-19 01/2022 - 01/2021
4	Neoplasms (Cancer) 04/2020 - 03/2015
4	Inflammation (Inflammations) 01/2020 - 03/2015
3	Cachexia 01/2021 - 01/2018
3	Hypertrophy 01/2021 - 01/2018
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 07/2020 - 12/2012
2	Fibrosis (Cirrhosis) 11/2014 - 02/2012
1	Muscular Atrophy (Muscle Atrophy) 01/2021
1	Reinfection 01/2021
1	Atrophy 01/2021
1	Coronavirus Infections 01/2021
1	Sarcopenia 04/2020
1	Seminoma 04/2020
1	Neuromuscular Diseases (Neuromuscular Disease) 04/2020
1	Pancreatitis 01/2020
1	Myocardial Infarction 01/2020
1	Heart Failure 01/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020
1	Metaplasia 01/2020
1	Reperfusion Injury 01/2019
1	Osteoporosis 01/2019
1	Polyploidy 01/2019
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019
1	Ischemia 01/2017
1	Acute Kidney Injury (Acute Renal Failure) 01/2017
1	Cysts 12/2016
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 12/2016
1	Hyperinsulinism (Hyperinsulinemia) 10/2015
1	Lung Injury 06/2015
1	Bronchopulmonary Dysplasia 06/2015
1	Hyperoxia 06/2015
1	Malignant Mesothelioma 03/2015
1	Mesothelioma 03/2015
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/2014
1	Idiopathic Pulmonary Fibrosis 11/2014
1	Emphysema 02/2012
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2012
1	Acute Lung Injury 02/2012

Drug/Important Bio-Agent (IBA)

11	Activins (Activin)IBA 01/2021 - 11/2014
8	activin AIBA 01/2021 - 02/2012
8	LigandsIBA 01/2021 - 12/2016
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2012
6	MyostatinIBA 01/2021 - 01/2019
3	activin BIBA 01/2021 - 11/2014
3	FollistatinIBA 01/2021 - 11/2014
3	Activin Receptors (Activin Receptor)IBA 01/2020 - 12/2016
2	VaccinesIBA 01/2022 - 01/2021
2	mRNA VaccinesIBA 01/2022 - 01/2021
2	Immunoglobulin G (IgG)IBA 01/2021 - 11/2014
2	DystrophinIBA 07/2020 - 12/2012
1	BNT162 VaccineIBA 01/2022
1	2019-nCoV Vaccine mRNA-1273IBA 01/2022
1	Neutralizing AntibodiesIBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	activin receptor type II-BIBA 01/2021
1	AntigensIBA 01/2021
1	EnzymesIBA 01/2021
1	Immunoglobulin A (IgA)IBA 01/2021
1	Immunoglobulin IsotypesIBA 01/2021
1	NucleoproteinsIBA 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2018
1	Glutathione (Reduced Glutathione)IBA 01/2018
1	AntioxidantsIBA 01/2018
1	Beclin-1IBA 01/2018
1	Endoplasmic Reticulum Chaperone BiPIBA 01/2018
1	TransglutaminasesIBA 01/2017
1	AutoantibodiesIBA 01/2017
1	Insulin (Novolin)FDA Link 10/2015
1	AsbestosIBA 03/2015
1	AntibodiesIBA 11/2014
1	Surface-Active Agents (Surfactants)IBA 02/2012

Therapy/Procedure

1	Transplantation 01/2017
1	Kidney Transplantation 01/2017